Abhay B. Mahindre

Noble hospital & Research Centre Pune,
India

Abstract Title:Insight in neonatal sepsis: Comparing two different NICU setup in western part of India

Biography:

Research Interest: Introduction: Neonatal sepsis is the most common cause of neonatal morbidity and mortality in India. Incidence of culture positive sepsis varies from 6% to 20% in different NICU set up in India. Aims & Objective: 1. To study the incidence of culture positive sepsis in two different hospitals in western part of India: Charitable teaching hospital NICU and Tertiary level III referring hospital NICU. 2. To find the most common organism in neonatal sepsis 3. To find mortality related to neonatal sepsis in NICU. Methods: Retrospective observational study for 1 year from 1st January 2024 to 31st December 2024. All the blood culture positive neonatal sepsis cases from two different institutes were analysed. Results: During the study period, 75 neonatal sepsis cases were diagnosed, among them 32 from tertiary level III referring NICU and 43 from charitable teaching hospital NICU. Incidence of culture positive sepsis is 6.08% at tertiary level III referring hospital NICU while is 8.28% charitable teaching hospital NICU. Gram-positive sepsis is more common in both the institute compared to gram-negative sepsis. Incidence of early onset sepsis is more common in charitable teaching institute while late onset sepsis is more common in tertiary level III referring hospital NICU. The culture sensitivity pattern varies in both the NICU. Neonatal mortality rate due to sepsis is comparable in both the institute. Conclusions: In the practice of modern neonatal care, culture positive neonatal sepsis remains the major concern in all NICU. Multidrug organisms are emerging at both the places. By practicing antibiotic stewardship individualised to the institute, infants can be protected from future multidrug resistance organisms. Keywords: Antibiotic stewardship, Neonate, Sepsis, Sensitivity