ZHAO Kang

XiuZhou medical University,
China

Abstract Title:Overnight Orthokeratology Combined with Atropine 0.01%+brinzolamide In Chinese Pre-adolescent Myopes

Biography:

Research Interest: Background Orthokeratology has been proved to temporarily alter the equivalent sphere. On condition that Orthokeratology combined with atropine 0.01% +brinzolamide trading myopia deserves attention. Purpose A comparative study was performed to evaluate the effectiveness of Orthokeratology alone, or Orthokeratology combined with atropine 0.01% and brinzolamide Chinese school-age samples. Methods: Myopia advance was examined in 158 participants (316 eyes) aged 9 to 14 years (mean ages 11.2 ±1.5 years, -0.5 to -3.00DS with astigmatism less than -1.25DC). The subjects are randomly assigned to orthokeratology atropine 0.01%+brinzolamide Orthokeratology group (n=63).The primary outcomes, which covered cycloplegic refraction, ocular biometry and topography measurements, were assessed every 6 months. The study was done in 36 months. Data were analyzed using ANOVA, repeated measured ANOVA and a chi-square tests. Results: 141 subjects (83 in Orthokeratology+ Atropine 0.01%+brinzolamiderthokeratology group) completed the three-year study. Over 3 years, axial length elongation in the Orthokeratology + Atropine 0.01% +brinzolamide Orthokeratology group, respectively, were 0.21 ± 0.12 mm, 0.32 ± 0.16 mm; and the spherical equivalent refractive (SER) error changes in the Orthokeratology group and the Orthokeratology+ atropine 0.01%+brinzolamide group , were -0.62±0.61 D, -0.43±0.66 D, Respectively. Conclusions: This study shows: A) that measure of intervention of myopia are one factor of influence on myopia progression; B) that compared with Orthokeratology group, myopia progression was found to be more retarded by orthokeratology+atropine 0.01%+brinzolamide in Chinese school-children.